Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
MK Shanmugam, AH Nguyen, AP Kumar, BKH Tan… - Cancer letters, 2012 - Elsevier
Over the last two decades, extensive research on plant-based medicinal compounds has
revealed exciting and important pharmacological properties and activities of triterpenoids. Fruits…
revealed exciting and important pharmacological properties and activities of triterpenoids. Fruits…
Key cell signaling pathways modulated by zerumbone: role in the prevention and treatment of cancer
…, A Nachiyappan, L Ramachandran, AH Nguyen… - Biochemical …, 2012 - Elsevier
Phytochemicals and their synthetic derivatives are making a significant contribution in modern
drug discovery programs by targeting several human diseases, including cancer. Most of …
drug discovery programs by targeting several human diseases, including cancer. Most of …
[HTML][HTML] Cardiac tissue engineering: state-of-the-art methods and outlook
AH Nguyen, P Marsh, L Schmiess-Heine… - Journal of biological …, 2019 - Springer
The purpose of this review is to assess the state-of-the-art fabrication methods, advances in
genome editing, and the use of machine learning to shape the prospective growth in cardiac …
genome editing, and the use of machine learning to shape the prospective growth in cardiac …
Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
…, JT Tarrasch, B Plouffe, AH Nguyen… - Proceedings of the …, 2017 - National Acad Sciences
β-Arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein
signaling, to initiate signaling on their own, and to mediate receptor endocytosis. Prior …
signaling, to initiate signaling on their own, and to mediate receptor endocytosis. Prior …
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells
A Ochi, AH Nguyen, AS Bedrosian… - Journal of Experimental …, 2012 - rupress.org
The transition of chronic pancreatic fibroinflammatory disease to neoplasia is a primary
example of the paradigm linking inflammation to carcinogenesis. However, the cellular and …
example of the paradigm linking inflammation to carcinogenesis. However, the cellular and …
Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: a pilot study
Background & Aims To evaluate the hypothesis that increasing T cell frequency and activity
may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a …
may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a …
Depressive symptoms and risk of stroke: the Framingham Study
KJ Salaycik, M Kelly-Hayes, A Beiser, AH Nguyen… - Stroke, 2007 - Am Heart Assoc
Background and Purpose— Emerging evidence raises the possibility of an association between
depression and stroke risk. This study sought to examine whether depressive symptoms …
depression and stroke risk. This study sought to examine whether depressive symptoms …
Role of stacking disorder in ice nucleation
The freezing of water affects the processes that determine Earth’s climate. Therefore, accurate
weather and climate forecasts hinge on good predictions of ice nucleation rates 1 . Such …
weather and climate forecasts hinge on good predictions of ice nucleation rates 1 . Such …
Identification of clathrate hydrates, hexagonal ice, cubic ice, and liquid water in simulations: The CHILL+ algorithm
AH Nguyen, V Molinero - The Journal of Physical Chemistry B, 2015 - ACS Publications
Clathrate hydrates and ice I are the most abundant crystals of water. The study of their
nucleation, growth, and decomposition using molecular simulations requires an accurate and …
nucleation, growth, and decomposition using molecular simulations requires an accurate and …
Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B
…, B Massetto, AH Nguyen, A Joshi, J Woo, AH Lau… - Journal of …, 2018 - Elsevier
Background & Aims Vesatolimod (GS-9620) is an oral agonist of toll-like receptor 7, an activator
of innate and adaptive immune responses. Herein the safety and efficacy of vesatolimod …
of innate and adaptive immune responses. Herein the safety and efficacy of vesatolimod …