Polyhydroxyalkanoates (PHAs), of which polyhydroxybutyrate (PHB) is the most abundant,
are bacterial carbon and energy reserve materials of widespread occurrence. They are …

Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T cell
responses and have proven to be effective targets in the setting of chronic diseases where …

Although older age is the greatest risk factor for osteoarthritis (OA), OA is not an inevitable
consequence of growing old. Radiographic changes of OA, particularly osteophytes, are …

Importance Antiretroviral therapy (ART) has improved life expectancy for individuals with HIV
infection, but recent data comparing life span and comorbidity-free years by HIV status are …

PET with [ 11 C]-(R)-PK11195 is currently the modality of choice for the in vivo imaging of
microglial activation in the human brain. In this work we devised a supervised clustering …

Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess
efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid …

The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …

In spite of a powerful tradition, more than two thousand years old, that in a valid argument
the premises must be relevant to the conclusion, twentieth-century logicians neglected the …

The idea that iron might limit phytoplankton growth in large regions of the ocean has been
tested by enriching an area of 64 km 2 in the open equatorial Pacific Ocean with iron. This …

MATERIALS AND METHODS Description of sampler. A photograph of the latest model of the
Andersen sampler is shown in figure 1, and a schematic diagram of the device is presented …