Should I fire my trader or pay him a million?

G Karz, WH Wagner - The Journal of Trading, 2006 - pm-research.com
Recent decades have seen increasing standards of professionalism being applied to buyside
equity securities traders. Traders are upgrading their roles in the investment organization, …

[PDF][PDF] Proteogenomic and metabolomic characterization of human glioblastoma

…, E Jaehnig, SD Jewell, N Ji, CD Jones, A Karz - Cancer cell, 2021 - cell.com
Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its
molecular pathogenesis is crucial to improving diagnosis and treatment. Integrated analysis of …

[PDF][PDF] Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma

…, M Hyrcza, SD Jewell, CD Jones, MH Kane, A Karz… - Cancer cell, 2021 - cell.com
We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …

[PDF][PDF] Dissecting the treatment-naive ecosystem of human melanoma brain metastasis

…, JC Melms, AD Amin, Y Wang, LA Caprio, A Karz… - Cell, 2022 - cell.com
Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma;
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …

[PDF][PDF] Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis

D Hanniford, A Ulloa-Morales, A Karz… - Cancer cell, 2020 - cell.com
Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms
governing metastatic spread may uncover important tumor biology and/or yield promising …

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

…, A Hall Hickman, S Zheng, V Roudko, S Chen, A Karz… - Elife, 2021 - elifesciences.org
… HNRNPM-bound sites tended to be guanidine and uridine (GU)-rich (Figure 3D, E), and
motif analyses of these sites revealed sequences consisting of single or double G residues inter…

Melanoma-secreted amyloid beta suppresses neuroinflammation and promotes brain metastasis

…, A Karz, D Argibay, R Von Itter, A Floristan, G Baptiste… - Cancer discovery, 2022 - AACR
Our results reveal a novel mechanistic connection between brain metastasis and Alzheimer's
disease, two previously unrelated pathologies; establish Aβ as a promising therapeutic …

Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities

A Karz, M Dimitrova, K Kleffman… - Pigment cell & …, 2022 - Wiley Online Library
Brain metastases are the most common brain malignancy. This review discusses the studies
presented at the third annual meeting of the Melanoma Research Foundation in the context …

[HTML][HTML] An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma

…, B Fontanals-Cirera, A Karz… - Nature …, 2023 - nature.com
g Heatmap representation of unsupervised cluster analysis of mean β-values showing …
CpGs depicted in heatmaps d and g are located between −300 to 63 bp relative to the NR2F2-…

The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis

…, I Dolgalev, SAA Shadaloey, D Argibay, A Karz… - Science …, 2022 - science.org
The contribution of epigenetic dysregulation to metastasis remains understudied. Through a
meta-analysis of gene expression datasets followed by a mini-screen, we identified Plant …