User profiles for L. Thukral
Lipi ThukralInstitute of Genomics and Integrative Biology Verified email at igib.in Cited by 15150 |
[HTML][HTML] Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …
Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India
…, P Sharma, A Vr, U Chaudhary, N Soni, L Thukral… - Science, 2021 - science.org
Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50…
coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50…
[HTML][HTML] An early warning system for emerging SARS-CoV-2 variants
Global sequencing and surveillance capacity for SARS-CoV-2 must be strengthened and
combined with multidisciplinary studies of infectivity, virulence and immune escape, in order …
combined with multidisciplinary studies of infectivity, virulence and immune escape, in order …
Membrane association of the ATG8 conjugation machinery emerges as a key regulatory feature for autophagosome biogenesis
Autophagy is a highly conserved intracellular pathway that is essential for survival in all
eukaryotes. In healthy cells, autophagy is used to remove damaged intracellular components, …
eukaryotes. In healthy cells, autophagy is used to remove damaged intracellular components, …
[HTML][HTML] SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion
The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and is characterised by
multiple spike mutations across all spike domains. Here we show that compared to the Delta …
multiple spike mutations across all spike domains. Here we show that compared to the Delta …
Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s
…, C Saito, C Davis, HBJ Jefferies, A Schreiber, L Thukral… - Elife, 2023 - elifesciences.org
Autophagy is an essential catabolic pathway which sequesters and engulfs cytosolic
substrates via autophagosomes, unique double-membraned structures. ATG8 proteins are …
substrates via autophagosomes, unique double-membraned structures. ATG8 proteins are …
Lipidated proteins: Spotlight on protein-membrane binding interfaces
The covalent attachment of lipids to proteins is a fundamental property of all living cells.
These lipidated or lipid-modified proteins are directly targeted to the membranes and display …
These lipidated or lipid-modified proteins are directly targeted to the membranes and display …
SARS-CoV-2 Omicron spike mediated immune escape and tropism shift
…, IG Goodfellow, NJ Matheson, L Thukral… - BioRxiv, 2021 - biorxiv.org
The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and is characterised by multiple
spike mutations across all spike domains. Here we show that Omicron BA.1 has higher …
spike mutations across all spike domains. Here we show that Omicron BA.1 has higher …
[HTML][HTML] A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme …
Cholesterol biosynthesis in the endoplasmic reticulum (ER) is tightly controlled by multiple
mechanisms to regulate cellular cholesterol levels. Squalene monooxygenase (SM) is the …
mechanisms to regulate cellular cholesterol levels. Squalene monooxygenase (SM) is the …
Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations
… Lipi Thukral… (1) C R k l = n c k l / N (1) where nc kl is the total number of frames when
residue k and l of protein A and B are in contact. N is the total no. of frames analyzed. …
residue k and l of protein A and B are in contact. N is the total no. of frames analyzed. …