Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
D Trachootham, J Alexandre, P Huang - Nature reviews Drug discovery, 2009 - nature.com
Increased generation of reactive oxygen species (ROS) and an altered redox status have
long been observed in cancer cells, and recent studies suggest that this biochemical property …
long been observed in cancer cells, and recent studies suggest that this biochemical property …
The European hernia society groin hernia classication: simple and easy to remember
M Miserez, JH Alexandre, G Campanelli, F Corcione… - Hernia, 2007 - Springer
After reviewing the available classifications for groin hernias, the European Hernia Society (EHS)
proposes an easy and simple classification based on the Aachen classification. The …
proposes an easy and simple classification based on the Aachen classification. The …
[HTML][HTML] Prevalence of adolescent problem gambling: A systematic review of recent research
… Moreover, 2.5 % of the total sample and 13.8 % of those who had gambling experience
were considered addicted online gamblers as classified by the DSM-IV-MR-J. Online gambling …
were considered addicted online gamblers as classified by the DSM-IV-MR-J. Online gambling …
[PDF][PDF] Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
E Raymond, J Alexandre, S Faivre, K Vera… - Journal of clinical …, 2004 - researchgate.net
… Eric Raymond and Jérôme Alexandre … Rohde J, Heitman J, Cardenas ME: The TOR
kinases link nutrient sensing to cell growth. … Dancey J, Sausville EA: Issues and progress …
kinases link nutrient sensing to cell growth. … Dancey J, Sausville EA: Issues and progress …
Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study
…, YH Park, JP Delord, A Italiano, J Alexandre… - The Lancet …, 2020 - thelancet.com
Background Poly (ADP-ribose) polymerase inhibitors combined with immunotherapy have
shown antitumour activity in preclinical studies. We aimed to assess the safety and activity of …
shown antitumour activity in preclinical studies. We aimed to assess the safety and activity of …
Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients
…, J Alexandre, C Kahatt, A Taamma, J Jimeno… - Journal of Clinical …, 2004 - ascopubs.org
Purpose A multicenter phase II study evaluating efficacy, safety, and pharmacokinetics of
ecteinascidin-743 (ET-743) in pretreated advanced soft tissue sarcoma patients. Patients and …
ecteinascidin-743 (ET-743) in pretreated advanced soft tissue sarcoma patients. Patients and …
Immune checkpoint inhibitor rechallenge after immune-related adverse events in patients with cancer
…, PU Milliez, V Lelong-Boulouard, J Alexandre - JAMA …, 2020 - jamanetwork.com
Importance Limited information is available on the safety of a rechallenge with an immune
checkpoint inhibitor (ICI) after an immune-related adverse event (irAE). Objective To identify …
checkpoint inhibitor (ICI) after an immune-related adverse event (irAE). Objective To identify …
Controlling tumor growth by modulating endogenous production of reactive oxygen species
…, C Nicco, C Chéreau, C Goulvestre, J Alexandre… - Cancer research, 2005 - AACR
Paradoxically, reactive oxygen species (ROS) can promote normal cellular proliferation and
carcinogenesis, and can also induce apoptosis of tumor cells. In this report, we study the …
carcinogenesis, and can also induce apoptosis of tumor cells. In this report, we study the …
Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species
J Alexandre, Y Hu, W Lu, H Pelicano, P Huang - Cancer research, 2007 - AACR
Generation of reactive oxygen species (ROS) has been observed in cancer cells treated with
paclitaxel, but the underlying mechanisms and therapeutic implications remain unclear. In …
paclitaxel, but the underlying mechanisms and therapeutic implications remain unclear. In …
Cardiovascular toxicity related to cancer treatment: a pragmatic approach to the American and European cardio‐oncology guidelines
J Alexandre, J Cautela, S Ederhy… - Journal of the …, 2020 - Am Heart Assoc
The considerable progress made in the field of cancer treatment has led to a dramatic
improvement in the prognosis of patients with cancer. However, toxicities resulting from these …
improvement in the prognosis of patients with cancer. However, toxicities resulting from these …