[HTML][HTML] Tumor associated macrophages: origin, recruitment, phenotypic diversity, and targeting
The tumour microenvironment (TME) is known to have a strong influence on tumourigenesis,
with various components being involved in tumour suppression and tumour growth. A …
with various components being involved in tumour suppression and tumour growth. A …
Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers
With the recent emergence of reports on resistant Gram-negative ‘superbugs’, infections
caused by multidrug-resistant (MDR) Gram-negative bacteria have been named as one of the …
caused by multidrug-resistant (MDR) Gram-negative bacteria have been named as one of the …
Differential roles of the protein corona in the cellular uptake of nanoporous polymer particles by monocyte and macrophage cell lines
…, CS Ang, NM O'Brien-Simpson, JC Lenzo… - ACS …, 2013 - ACS Publications
Many biomolecules, mainly proteins, adsorb onto polymer particles to form a dynamic protein
corona in biological environments. The protein corona can significantly influence particle–…
corona in biological environments. The protein corona can significantly influence particle–…
[HTML][HTML] The potential of modified and multimeric antimicrobial peptide materials as superbug killers
T Matthyssen, W Li, JA Holden, JC Lenzo… - Frontiers in …, 2022 - frontiersin.org
Antimicrobial peptides (AMPs) are found in nearly all living organisms, show broad spectrum
antibacterial activity, and can modulate the immune system. Furthermore, they have a very …
antibacterial activity, and can modulate the immune system. Furthermore, they have a very …
[HTML][HTML] The potential of calcium phosphate nanoparticles as adjuvants and vaccine delivery vehicles
Z Sun, W Li, JC Lenzo, JA Holden… - Frontiers in …, 2021 - frontiersin.org
Vaccination is one of the most efficacious and cost-effective ways to protect people from
infectious diseases and potentially cancer. The shift in vaccine design from disrupted whole …
infectious diseases and potentially cancer. The shift in vaccine design from disrupted whole …
Macrophage depletion abates Porphyromonas gingivalis–induced alveolar bone resorption in mice
RS Lam, NM O'Brien-Simpson, JC Lenzo… - The Journal of …, 2014 - journals.aai.org
The role of the macrophage in the immunopathology of periodontitis has not been well
defined. In this study, we show that intraoral inoculation of mice with Porphyromonas gingivalis …
defined. In this study, we show that intraoral inoculation of mice with Porphyromonas gingivalis …
[HTML][HTML] Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo
JD Cecil, NM O'Brien-Simpson, JC Lenzo… - Frontiers in …, 2017 - frontiersin.org
… To evaluate the inflammatory potential of OMVs in vivo we compared the stimulation of
C57BL/6 J mice treated with intraperitoneal injections of phosphate-buffered saline (PBS), …
C57BL/6 J mice treated with intraperitoneal injections of phosphate-buffered saline (PBS), …
The promotion of breast cancer metastasis caused by inhibition of CSF-1R/CSF-1 signaling is blocked by targeting the G-CSF receptor
A Swierczak, AD Cook, JC Lenzo, CM Restall… - Cancer immunology …, 2014 - AACR
Abstract Treatment options are limited for patients with breast cancer presenting with metastatic
disease. Targeting of tumor-associated macrophages through the inhibition of colony-…
disease. Targeting of tumor-associated macrophages through the inhibition of colony-…
Control of macrophage lineage populations by CSF‐1 receptor and GM‐CSF in homeostasis and inflammation
JC Lenzo, AL Turner, AD Cook… - Immunology and cell …, 2012 - Wiley Online Library
Control of macrophage lineage populations by CSF‐1 receptor and GM‐CSF in homeostasis
and inflammation - Lenzo - 2012 - Immunology & Cell … Jason C Lenzo … Jason C Lenzo …
and inflammation - Lenzo - 2012 - Immunology & Cell … Jason C Lenzo … Jason C Lenzo …
[HTML][HTML] Differential responses of pattern recognition receptors to outer membrane vesicles of three periodontal pathogens
JD Cecil, NM O'Brien-Simpson, JC Lenzo, JA Holden… - PLoS …, 2016 - journals.plos.org
Highly purified outer membrane vesicles (OMVs) of the periodontal pathogens, Porphyromonas
gingivalis, Treponema denticola and Tannerella forsythia were produced using …
gingivalis, Treponema denticola and Tannerella forsythia were produced using …