Background Physical exercise is seen as a promising intervention to prevent or delay
cognitive decline in individuals aged 50 years and older, yet the evidence from reviews is not …

Biomechanical and biochemical cues within a tissue collaborate across length scales to
direct cell fate during development and are critical for the maintenance of tissue homeostasis. …

Physical activity has received substantial research attention due to its beneficial impact on
cognition in ageing, particularly via the action of brain-derived neurotrophic factor (BDNF). It is …

Metabolic adaptations play a key role in fueling tumor growth. However, less is known regarding
the metabolic changes that promote cancer progression to metastatic disease. Herein, …

Background The antiviral drug molnupiravir was licensed for treating at-risk patients with
COVID-19 on the basis of data from unvaccinated adults. We aimed to evaluate the safety and …

Chlorophyll (chl) is essential for light capture and is the starting point that provides the energy
for photosynthesis and thus plant growth. Obviously, for this reason, retention of the green …

Women with dense breasts have an increased lifetime risk of malignancy that has been
attributed to a higher epithelial density. Quantitative proteomics, collagen analysis, and …

Intratumor heterogeneity associates with poor patient outcome. Stromal stiffening also
accompanies cancer. Whether cancers demonstrate stiffness heterogeneity, and if this is linked to …

Targeted protein degradation is an emerging strategy for the elimination of classically
undruggable proteins. Here, to expand the landscape of targetable substrates, we designed …

Molnupiravir is an antiviral, currently approved by the UK Medicines and Healthcare products
Regulatory Agency (MHRA) for treating at-risk COVID-19 patients, that induces lethal error …